Transcriptome Analysis of the Marine Nematode Litoditis marina in a Chemically Defined Food Environment with Stearic Acid Supplementation

Stearic acid represents one of the most abundant fatty acids in Western diet and profoundly regulates health diseases animals human beings. We previously showed that stearic supplementation promoted development terrestrial model nematode Caenorhabditis elegans chemically defined CeMM food environment. However, whether other nematodes remains unknown. Here, we found dietary with could promote marine Litoditis marina, belonging to same family as C. elegans, indicating conserved roles developmental regulation. further employed transcriptome analysis analyze genome-wide transcriptional signatures L. marina supplementation. might via upregulation expression genes involved aminoacyl-tRNA biosynthesis, translation initiation elongation, ribosome biogenesis, transmembrane transport. In addition, observed neuronal signaling-related was decreased. This study provided important insights into how a single nematode, studies CRISPR genome editing will facilitate demonstrating molecular mechanisms underlying metabolite animal health.